Cain left with a no-decision in his first start in a 3-2 loss at Los Angeles on Tuesday. The right-hander allowed three hits over 5 2/3 shutout innings with four walks and five strikeouts.
"I just need to focus on staying with my routine," Cain said. "I think after the first pitch I'll kind of settle down a little. You kind of get the jitters being the home opener. You just try and get as relaxed as you can."
The Padres will counter with right-hander Greg Maddux. The future Hall of Famer also recorded a no-decision in a 9-6 loss against Houston on Wednesday.
"I've faced him a ton of times," Cain said. "It seems like me and him match up a lot. You have to get used to the ball moving everywhere. I think he's worked me over a couple times. I definitely can't hit off him."
The Giants begin a much-needed 10-game homestand. San Francisco plays a three-game series against San Diego, a four-game series against St. Louis and a three-game stand against Arizona.
"We're a week into a very long season," Zito said. "A lot of positive things can happen this year. We didn't give [the fans] a flashy start, but there's a reason to watch and a reason to be excited."
SF: RHP Matt Cain (0-0, 0.00 ERA)
Cain excelled in his first start of the season, blanking Los Angeles for 5 2/3 innings on three hits. He received no decision in the Giants' 3-2 loss. Cain acknowledged that he should have lasted longer, but too many deep counts forced him to leave after throwing 113 pitches. This will be Cain's 12th start against the Padres, his most against any club. He owns a 3-3 record with a 2.07 ERA lifetime against San Diego, although that includes an 0-3, 2.41 showing last year.
SD: RHP Greg Maddux (0-0, 4.50 ERA)
Maddux struggled in his first start of the season, allowing six runs (four of which were earned) over six innings against the Astros on Wednesday. He elevated more than a few balls, three of which ended up as home runs. Still, Maddux kept himself in the game as the 17-time Gold Glove winner made several nice defensive plays. He didn't allow a walk, which wasn't surprising considering the strech of 59 2/3 innings he pitched last season without allowing a walk.
Giants rookie catcher Steve Holm went 1-for-3 with a single in his first Major League start Sunday. It was one of five hits allowed by Brewers ace Ben Sheets. ... San Francisco plays 16 of its next 23 games at AT&T Park. ... The Giants pitching staff allowed 25 runs on 37 hits in the three-game series at Milwaukee. ... The San Francisco offense didn't score a run in the first four innings of its six games.
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Official game notes
KNBR 680, KLOK 1170 (Español)
Tuesday: Giants (Tim Lincecum, 1-0, 2.25) vs. Padres (Randy Wolf, 0-0, 1.50), 7:15 p.m. PT
Wednesday: Giants (Jonathan Sanchez, 0-1, 15.75) vs. Padres (Justin Germano, 0-0, 0.00), 7:15 p.m. PT
Thursday: Giants (Kevin Correia, 0-1, 6.00) vs. Cardinals (Adam Wainwright, 1-0, 2.25), 7:15 p.m. PT