"He's pretty sore there," Giants manager Bruce Bochy said Wednesday. "This is not good news for us. We just got him back and he was playing well."
After Wednesday's 7-3 loss to the Nationals, the Giants announced they were calling up infielder Ryan Rohlinger from Triple-A Fresno.
Renteria, who was 4-for-10 with an RBI in three games since returning from his last stint on the disabled list with a strained groin muscle, pulled his right hamstring while running to first base on a seventh-inning sacrifice bunt.
"We'll probably have to take a little time to get him back on the field," Bochy said. "We're talking about another player."
In addition to utility man Juan Uribe and Rohlinger, Bochy's options at shortstop include using Matt Downs or Freddy Sanchez on a short-term basis.
"Matt has taken ground balls there," Bochy said. "He's been working there. Even Sanchez could do it for a game."